| Pharyngeal acid reflux events in patients with vocal cord nodules. | |
| | |
MedLine Citation:
|
PMID: 9707233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Gastroesophageal reflux has been implicated in the pathogenesis of vocal cord nodules. However, a cause-and-effect relationship has not been established. Because documentation of pharyngeal acid reflux events makes this correlation more plausible, the aim of the present study was to determine the frequency of pharyngeal acid reflux events in patients with vocal cord nodules. METHODS: Eleven patients with vocal cord nodules (mean age, 42 +/- 6 years) and eleven healthy volunteers (mean age, 45 +/- 6 years) were studied. Patients underwent barium esophagram and ambulatory 24-hour simultaneous three-site pharyngoesophageal pH monitoring. Controls only had ambulatory 24-hour simultaneous three-site pH monitoring. In the ambulatory pH monitoring studies, pH was recorded from the manometrically determined sites of pharynx (2 cm above upper esophageal sphincter), proximal esophagus (10 cm distal to pharyngeal site), and distal esophagus (5 cm above the lower esophageal sphincter). Pharyngeal acid reflux event was deemed acceptable if all three sites recorded a decrease in pH below 4 which was not related to meal or drinking. RESULTS: Pharyngeal acid reflux events occurred in seven of 11 patients with vocal cord nodules (1-4 episodes) and two of 11 controls (1-2 episodes) (P < .05). In both groups all pharyngeal acid reflux events occurred in upright position and were not associated with belching or coughing. Barium studies documented hiatal hernia in two patients and gastroesophageal reflux in five of 11 patients. However, none of the esophageal reflux events reached the pharynx on barium esophagram. CONCLUSIONS: Prevalence of pharyngeal acid reflux events is significantly higher in patients with vocal cord nodules compared with normal controls and suggests a contributory role for gastroesophagopharyngeal acid reflux in the pathogenesis of some vocal cord nodules. |
| | |
Authors:
|
J Kuhn; R J Toohill; S O Ulualp; J Kulpa; C Hofmann; R Arndorfer; R Shaker |
Related Documents
:
|
2787643 - Pharmacological profile of the new anticonvulsant etazepine. 9642333 - Effects of peroxovanadate complexes on reducing glycemia in diabetic rats and transloca... 17929193 - Chlorosome lipids from chlorobium tepidum: characterization and quantification of polar... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Laryngoscope Volume: 108 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 1998 Aug |
Date Detail:
|
Created Date: 1998-08-27 Completed Date: 1998-08-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1146-9 Citation Subset: IM |
Affiliation:
|
MCW Dysphagia Institute, Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Esophagus / radiography Female Gastroesophageal Reflux / complications*, diagnosis, radiography Humans Hydrogen-Ion Concentration Laryngeal Diseases / etiology Male Middle Aged Monitoring, Ambulatory Pharynx / metabolism Vocal Cords* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DK25731/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A longitudinal, functional study of peripheral nerve recovery in the mouse.
Next Document: Neck dissection with simultaneous carotid endarterectomy.