| Pharyngeal (Zenker's) diverticulum is a disorder of upper esophageal sphincter opening. | |
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MedLine Citation:
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PMID: 1397879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharyngeal coordination, sphincter opening, and flow pressures during swallowing were investigated in patients with pharyngeal (Zenker's) diverticula. Fourteen patients with diverticula and 9 healthy age-matched controls were studied using simultaneous videoradiography and manometry. Pharyngeal and upper esophageal sphincter pressures were recorded by a perfused side hole/sleeve assembly. Temporal relationships among swallowing events, extent of sphincter opening during swallowing, and intrabolus pressure during bolus passage across the sphincter were measured. The timing among pharyngeal contraction and sphincter relaxation, opening, and closure did not differ between patients and controls. Sphincter opening was significantly reduced in patients compared with controls in sagittal (P = 0.0003) and transverse (P = 0.005) planes. Manometric sphincter relaxation was normal in patients. Intrabolus pressure was significantly greater in patients than in controls (P = 0.001). It is concluded that Zenker's diverticulum is a disorder of diminished upper esophageal sphincter opening that is not caused by pharyngosphincteric incoordination or failed sphincter relaxation. Incomplete sphincter opening is likely to cause dysphagia. Increased hypopharyngeal pressures during swallowing are probably important in the pathogenesis of the diverticulum. |
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Authors:
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I J Cook; M Gabb; V Panagopoulos; G G Jamieson; W J Dodds; J Dent; D J Shearman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 103 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-10-26 Completed Date: 1992-10-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1229-35 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Adelaide, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Esophagogastric Junction / physiopathology* Female Humans Male Middle Aged Muscle Relaxation Pressure Zenker Diverticulum / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01-DC00669/DC/NIDCD NIH HHS; R01-DK25731/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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