| Pharmacotherapy for treatment-refractory schizophrenia. | |
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MedLine Citation:
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PMID: 21254948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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despite advances in pharmacotherapy of schizophrenia-spectrum disorders, a large percentage of persons with schizophrenia remain at least partially nonresponsive to treatment, leading to increased morbidity/mortality, increased healthcare cost, and poor quality of life for affected individuals. AREAS COVERED: this paper comprises a review of recent research in drug therapy for schizophrenia, particularly treatment-refractory schizophrenia, with a focus on research conducted between 2005 and June 2010. Databases that were searched include: Pubmed, CINAHL, Science Direct, Medline and Clinical Trials.gov. Primary search terms were 'treatment-refractory schizophrenia' and 'treatment-resistant schizophrenia', with cross reference to specific agents covered in this article. An objective perspective on current trends in pharmacotherapy for treatment-refractory schizophrenia. We review the available evidence and discuss the strengths and weaknesses of published data in this field. EXPERT OPINION: although there have been many advances in pharmacotherapy for schizophrenia, more well-designed trials are required to establish true efficacy and safety of current prescribing trends in clinical practice. |
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Authors:
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Scott P Van Sant; Peter F Buckley |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 12 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: 2011-04-20 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 411-34 Citation Subset: IM |
Affiliation:
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Medical College of Georgia, Department of Psychiatry and Health Behavior, Augusta, GA 30912, USA. svansant@mcg.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipsychotic Agents / therapeutic use* Clozapine / therapeutic use Drug Resistance Electroconvulsive Therapy / methods Health Care Costs Humans Quality of Life* Schizophrenia / drug therapy*, physiopathology, therapy Transcranial Magnetic Stimulation / methods |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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