| Pharmacotherapy for severe aggression in a child with autism: "open label" evaluation of multiple medications on response frequency and intensity of behavioral intervention. | |
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MedLine Citation:
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PMID: 11494958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many persons who have developmental disabilities and challenging behaviors are treated with multiple medications combined with nonpharmacological approaches. However, the comparative effects from pharmacotherapy frequently are not assessed empirically, do not include corollary behavioral measures, and are not evaluated in the long term. The present single-case study incorporated behavioral assessment methodology in an "open label" evaluation of anticonvulsant (clonazepam), beta-blocking (propanolol), and antidepressant (sertraline and clomipramine) medications on severe aggression in a child with autism. Clinically significant reductions in aggressive behavior were attained with the administration of clomipramine and the reductive effects from the medication persisted for 1.7 years. In addition, clomipramine was associated with the elimination of crisis intervention procedures that had been required to manage the child's aggression. These findings add to the clinical literature describing effective treatment of serious behavior disorders in persons with developmental disabilities using antidepressant medication. |
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Authors:
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J K Luiselli; P Blew; J Keane; S Thibadeau; T Holzman |
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Publication Detail:
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Type: Case Reports; Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of behavior therapy and experimental psychiatry Volume: 31 ISSN: 0005-7916 ISO Abbreviation: J Behav Ther Exp Psychiatry Publication Date: 2000 Sep-Dec |
Date Detail:
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Created Date: 2001-08-09 Completed Date: 2001-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245075 Medline TA: J Behav Ther Exp Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 219-30 Citation Subset: IM |
Affiliation:
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The May Institute Inc., One Commerce Place, Norwood, MA 02062, USA. jluiselli@mayinstitute.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aggression
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drug effects* Autistic Disorder / diagnosis, drug therapy*, parasitology Child Clomipramine / administration & dosage*, adverse effects Clonazepam / administration & dosage*, adverse effects Crisis Intervention Dose-Response Relationship, Drug Drug Administration Schedule Follow-Up Studies Humans Male Propranolol / administration & dosage*, adverse effects Sertraline / administration & dosage*, adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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1622-61-3/Clonazepam; 303-49-1/Clomipramine; 525-66-6/Propranolol; 79617-96-2/Sertraline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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