| Pharmacotherapy of polycystic ovary syndrome - an update. | |
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MedLine Citation:
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PMID: 21210850 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Polycystic ovary syndrome (PCOS) is a persisting challenge to clinical and basic research scientists as none of the presently available medications have been fully able to combat these consequences. The aim of the present review is to summarize the different lines of treatment available for the different symptomologies that women with PCOS presents. In this comprehensive review, search was made for various treatment options available for PCOS by using Cochrane library, Pubmed, Medline, in addition to the relevant printed medical journals and periodicals. The search results revealed that oral contraceptives containing oestrogen and progesterone regularize the menstruation, antiandrogens like spironolactone and drosperinone have proven to be effective in hirsutism and acne, clomiphene is the gold standard for ovulation induction, but multiple pregnancies and clomiphene failure add to its limitation. Hence, aromatase inhibitors like letrozole, low-dose gondotropins, and ovarian drilling procedure have shown to be beneficial effect in clomiphene-resistant cases. Insulin sensitizers such as metformin, thiazolidinediones, and d-chiro-inositol increase insulin sensitivity and improve ovulation rate. Recently, melatonin, N-acetyl cysteine, acarbose, and statins have shown positive results in different symptomologies of PCOS. The results show that PCOS treatment constitutes varied line of treatment depending upon the clinical features with which a woman is presenting. Still, unfortunately, none of the treatments are fully able to combat the PCOS. |
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Authors:
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Lekha Saha; Sharonjeet Kaur; Pradip Kumar Saha |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-7 |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: - ISSN: 1472-8206 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique. |
Affiliation:
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Institute of Medical Education and Research (PGIMER), Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh-160012, India Department of OBG, Government Medical College and Hospital, Sector-32, Chandigarh-160030, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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