| Pharmacotherapy of obesity. | |
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MedLine Citation:
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PMID: 17115344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity has become a significant health problem in industrialised and developing countries, and despite all nutritional and behavioural approaches, its prevalence is still increasing. In recent years, the identification and characterisation of central and peripheral mechanisms involved in the regulation of energy balance has made remarkable progress and provided numerous targets for novel anti-obesity agents. However, only few anti-obesity drugs are on the market and not many compounds have entered clinical development. In the present review, the clinically available agents are discussed and their pharmacological profiles are compared. Some of the drugs that are currently in clinical development are mentioned as examples of the possible future range of anti-obesity agents. Selected topics in drug discovery are presented to illustrate novel targets and concepts for the pharmacotherapy of obesity. |
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Authors:
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K G Hofbauer; J R Nicholson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 114 ISSN: 0947-7349 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-02-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 475-84 Citation Subset: IM |
Affiliation:
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Applied Pharmacology, Biozentrum/Pharmazentrum, University of Basel, Basel, Switzerland. karl.hofbauer@unibas.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Obesity Agents
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therapeutic use* Clinical Trials as Topic Cyclobutanes / therapeutic use Drug Design Energy Metabolism / drug effects Homeostasis / drug effects Humans Lactones / therapeutic use Life Style Models, Biological Obesity / drug therapy*, surgery Piperidines / therapeutic use Pyrazoles / therapeutic use Technology, Pharmaceutical / trends |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Cyclobutanes; 0/Lactones; 0/Piperidines; 0/Pyrazoles; 106650-56-0/sibutramine; 158681-13-1/rimonabant; 96829-58-2/orlistat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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