Document Detail

Pharmacotherapy: non-serotonergic mechanisms.
MedLine Citation:
PMID:  12077075     Owner:  NLM     Status:  MEDLINE    
Antidepressants rapidly relieve pain in irritable bowel syndrome (IBS) and are effective at low doses. Noradrenaline reuptake inhibitors appear to be more effective than selective serotonergic reuptake inhibitors, suggesting that pathways other than those modulated by serotonin may be involved in visceral sensation. Visceral sensitivity is reduced by both centrally and peripherally acting opioids, suggesting the possible existence of an endogenous opioid deficiency in patients with IBS. The alpha(2) adrenoceptor antagonist clonidine, as well as somatostatin, oxytocin, and possibly amitriptyline have also been shown to act as visceral analgesics. As knowledge increases, there are undoubtedly many other possible targets, and new drugs currently undergoing development may provide future benefit in patients with IBS.
R Spiller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gut     Volume:  51 Suppl 1     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-21     Completed Date:  2002-08-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  i87-90     Citation Subset:  AIM; IM    
Division of Gastroenterology, University Hospital, Notttingham, UK.
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MeSH Terms
Adrenergic Uptake Inhibitors / therapeutic use
Antidepressive Agents / therapeutic use*
Colonic Diseases, Functional / drug therapy*
Nociceptors / drug effects*
Sensation / drug effects*
Serotonin Uptake Inhibitors / therapeutic use
Visceral Afferents / drug effects*
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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