Document Detail

Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder.
MedLine Citation:
PMID:  10429138     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the risk for substance use disorders (SUD) associated with previous exposure to psychotropic medication in a longitudinal study of boys with attention-deficit/hyperactivity disorder (ADHD). METHODS: The cumulative incidence of SUD throughout adolescence was compared in 56 medicated subjects with ADHD, 19 nonmedicated subjects with ADHD, and 137 non-ADHD control subjects. RESULTS: Unmedicated subjects with ADHD were at a significantly increased risk for any SUD at follow-up compared with non-ADHD control subjects (adjusted OR: 6.3 [1.8-21.6]). Subjects with ADHD medicated at baseline were at a significantly reduced risk for a SUD at follow-up relative to untreated subjects with ADHD (adjusted OR: 0.15 [0.04-0.6]). For each SUD subtype studied, the direction of the effect of exposure to pharmacotherapy was similar to that seen for the any SUD category. CONCLUSIONS: Consistent with findings in untreated ADHD in adults, untreated ADHD was a significant risk factor for SUD in adolescence. In contrast, pharmacotherapy was associated with an 85% reduction in risk for SUD in ADHD youth.
J Biederman; T Wilens; E Mick; T Spencer; S V Faraone
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  104     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-13     Completed Date:  1999-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  e20     Citation Subset:  IM    
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / complications,  drug therapy*
Case-Control Studies
Central Nervous System Stimulants / adverse effects,  therapeutic use*
Longitudinal Studies
Regression Analysis
Risk Factors
Substance-Related Disorders / epidemiology,  etiology*
Grant Support
Reg. No./Substance:
0/Central Nervous System Stimulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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