Document Detail


The Pharmacotherapy of Heparin-Induced Thrombocytopenia (HIT) : A Review of Contemporary Therapeutic Challenges in Clinical Practice.
MedLine Citation:
PMID:  22589618     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Our objectives were to discuss a general overview on the description and recognition of heparin-induced thrombocytopenia (HIT) and present a critical review of the traditional and most recent advances in its pharmacotherapy. Computerized searches were done on MEDLINE and Iowa Drug Information Service (IDIS) databases from June 2001 until June 2007 and from May 2005 until May 2007, respectively. Search terms used included 'heparin-induced thrombocytopenia', 'heparin-associated thrombocytopenia', therapeutics, HIT, HAT. We largely selected publications within the timeframe above, but did not exclude commonly referenced and highly regarded older publications. The commonly referenced published articles were obtained through manual searches derived from bibliographic citations and retrievals from the authors' personal files. Pertinent literatures (89 key articles) that were thought to have substantially contributed new information to the therapeutics of HIT within the last 6 years were identified, reviewed and presented. The following limits were used for the MEDLINE and IDIS searches: 'human', drug therapy', 'review', 'meta-analysis', 'clinical trial', and case reports. The therapeutics of HIT is rapidly evolving and needs to consider an evidence - based approach. It is imperative that practitioners be aware of the associated risk and be up-to-date with the current advances in the management of this fatal clinical condition.
Authors:
Yahaya Hassan; Ahmed Awaisu; Ahmad Abdulrahman Al-Meman; Noorizan Abd Aziz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Malaysian journal of medical sciences : MJMS     Volume:  15     ISSN:  1394-195X     ISO Abbreviation:  Malays J Med Sci     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101126308     Medline TA:  Malays J Med Sci     Country:  Malaysia    
Other Details:
Languages:  eng     Pagination:  3-13     Citation Subset:  -    
Affiliation:
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
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