| Pharmacomodulation of high-density lipoprotein metabolism as a therapeutic intervention for atherosclerotic disease. | |
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MedLine Citation:
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PMID: 20740329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The high-density lipoproteins (HDLs) are produced by the liver and small intestine as well as on the surface of lipid-enriched macrophages in the subendothelial space of arterial walls. Unlike the apo B100-containing lipoproteins, the HDLs are uniquely antiatherogenic. Based on prospective observational studies performed throughout the world, there is a consistent inverse relationship between serum levels of HDLs and risk for cardiovascular events: low levels of high-density lipoprotein-cholesterol (HDL-C) are associated with increased risk, whereas high levels are usually associated with reduced risk for myocardial infarction, ischemic stroke, and cardiovascular mortality. Post hoc analyses of a number of studies using statins and fibrates have shown that raising serum HDL-C correlates with a reduction in risk for cardiovascular morbidity and mortality. Given these observations, enormous resources are being committed to the development of novel means by which to pharmacologically increase rates of HDL biosynthesis, modulate the functionality of HDL, and to promote reverse cholesterol transport with intravenous infusions of HDL particles. |
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Authors:
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Peter P Toth |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 12 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 481-7 Citation Subset: IM |
Affiliation:
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Sterling Rock Falls Clinic, 101 East Miller Road, Sterling, IL 61081, USA. peter.toth@srfc.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / drug therapy* Cholesterol Ester Transfer Proteins / antagonists & inhibitors Cholesterol, HDL / drug effects*, metabolism Humans Hypolipidemic Agents / pharmacology, therapeutic use Indoles / therapeutic use Lipid Metabolism / drug effects* Risk Assessment Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol Ester Transfer Proteins; 0/Cholesterol, HDL; 0/Hypolipidemic Agents; 0/Indoles; 0/MK-0524 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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