| Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation. | |
| | |
MedLine Citation:
|
PMID: 22967833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to estimate pharmacokinetic parameters and to evaluate placental transport of 17-hydroxyprogesterone caproate (17-OHPC) in singleton gestation. STUDY DESIGN: Sixty-one women who received weekly injections of 17-OHPC underwent 2 pharmacokinetic studies at 20 + 0 to 24 + 6 weeks' gestation (study 1) and 31 + 0 to 34 + 6 weeks' gestation (study 2); daily blood samples were obtained between injections. In 18 women, blood samples were obtained over a 28-day period beyond the last injection (extended study). Maternal and/or cord blood were obtained at delivery. RESULTS: The half-life (median ± SD) of 17-OHPC was 16.2 ± 6 days. Concentrations of 17-OHPC were higher during study 2 than during study 1. Body mass index affected maternal 17-OHPC concentrations. Cord:maternal 17-OHPC concentration ratios averaged 0.2; 17-OHPC was detectible in cord plasma 44 days after the last maternal injection. CONCLUSION: The apparent half-life of 17-OHPC is long, and pharmacokinetic parameters vary widely between subjects and are affected by maternal body mass index. The drug crosses the placental barrier. |
| | |
Authors:
|
Steve N Caritis; Shringi Sharma; Raman Venkataramanan; Gary D Hankins; Menachem Miodovnik; Mary F Hebert; Jason G Umans; Thomas Benedetti; Donald Mattison; Anne Zajicek; Dawn Fischer; Aimee Jackson; |
Related Documents
:
|
3678503 - Arrested tubal pregnancy. 11134843 - Simultaneous bilateral tubal pregnancy after intracytoplasmic sperm injection treated b... 7373603 - Acute fatty metamorphosis of pregnancy. a maternal mortality and literature review. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural Date: 2012-08-16 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 207 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-30 Completed Date: 2013-01-22 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 398.e1-8 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biological Transport / physiology Body Mass Index Female Fetal Blood / chemistry Humans Hydroxyprogesterones / blood, pharmacokinetics*, pharmacology Placenta / metabolism* Pregnancy Progestins / blood, pharmacokinetics*, pharmacology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
1 UL1RR031975/RR/NCRR NIH HHS; U10HD047892/HD/NICHD NIH HHS; U10HD047905/HD/NICHD NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS; UL1 TR000101/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxyprogesterones; 0/Progestins; 630-56-8/17-alpha-hydroxy-progesterone caproate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deep brain stimulation induces BOLD activation in motor and non-motor networks: An fMRI comparison s...
Next Document: Proteases are associated with a minor fucoxanthin chlorophyll a/c-binding protein from the diatom, C...