| Pharmacology and clinical experience with simvastatin. | |
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MedLine Citation:
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PMID: 11336576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Simvastatin (Zocortrade mark, Merck) is a safe and effective 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Simvastatin potently lowers total and low density lipoprotein (LDL) cholesterol. Simvastatin was the first cholesterol-lowering agent that reduced total mortality in a randomised clinical trial. Simvastatin is effective at reducing total mortality, myocardial infarction, coronary mortality and the incidence of stroke or transient ischemic attack in patients with coronary heart disease and hypercholesterolemia. Simvastatin, like other statins, also has non-lipid mechanisms of action. These include anti-inflammatory effects, antiproliferative effects on smooth muscle cells and an upregulation of endothelial nitric oxide synthase. Overall, simvastatin has an excellent safety profile. Simvastatin, along with other statins, has made a significant impact on the morbidity and mortality from coronary heart disease. |
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Authors:
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D C Hess; S C Fagan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 2 ISSN: 1465-6566 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-05-04 Completed Date: 2002-10-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 153-63 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA. dhess@neuro.mcg.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arteriosclerosis / drug therapy, etiology Cholesterol, LDL / blood Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Clinical Trials, Phase III as Topic Coronary Disease / prevention & control Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects, pharmacology*, therapeutic use* Hypercholesterolemia / blood, complications, drug therapy* Simvastatin / adverse effects, pharmacology*, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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