| Pharmacology of cardiovascular gap junctions. | |
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MedLine Citation:
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PMID: 16646587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gap junction (GJ) channels play an important role in forming a functional network or syncytium of cells by allowing the transfer of small molecules or the conduction of electrical activation. These channels can be regulated at the level of acute opening or closure as well as at the level of expression including synthesis, protein trafficking and degradation. Many of the underlying mechanisms depend on phosphorylation or dephosphorylation of connexins. A number of drugs is available to study GJ function and connexin expression. Some of these drugs have shown therapeutic effects, e.g. the anti-arrhythmic peptides AAP10 and ZP123 in the prevention of certain types of arrhythmia. Moreover, mediators involved in cardiovascular pathophysiology, e.g. angiotensin, endothelin, tumor necrosis factor-alpha, fibroblast growth factor and others, affect connexin expression and can alter the Cx43/Cx40 ratio, which may contribute to the formation of an arrhythmogenic substrate. On the other hand, drugs affecting these mediators may influence GJ networking and may thus open new therapeutic horizons. |
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Authors:
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Jean-Claude Hervé; Stefan Dhein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in cardiology Volume: 42 ISSN: 0065-2326 ISO Abbreviation: Adv Cardiol Publication Date: 2006 |
Date Detail:
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Created Date: 2006-05-01 Completed Date: 2006-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270063 Medline TA: Adv Cardiol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 107-31 Citation Subset: IM |
Affiliation:
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Equipe, Interactions et Communications Cellulaires, IPBC, CNRS-Université de Poitiers, Poitiers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / physiology Connexins / drug effects, metabolism Down-Regulation / physiology Gap Junctions / drug effects*, physiology Heart / physiology* Humans Oligopeptides / pharmacology Phosphorylation Up-Regulation / physiology |
| Chemical | |
Reg. No./Substance:
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0/AAP 10; 0/Connexins; 0/Oligopeptides; 355151-12-1/rotigaptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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