Document Detail

Pharmacology of cardiovascular gap junctions.
MedLine Citation:
PMID:  16646587     Owner:  NLM     Status:  MEDLINE    
Gap junction (GJ) channels play an important role in forming a functional network or syncytium of cells by allowing the transfer of small molecules or the conduction of electrical activation. These channels can be regulated at the level of acute opening or closure as well as at the level of expression including synthesis, protein trafficking and degradation. Many of the underlying mechanisms depend on phosphorylation or dephosphorylation of connexins. A number of drugs is available to study GJ function and connexin expression. Some of these drugs have shown therapeutic effects, e.g. the anti-arrhythmic peptides AAP10 and ZP123 in the prevention of certain types of arrhythmia. Moreover, mediators involved in cardiovascular pathophysiology, e.g. angiotensin, endothelin, tumor necrosis factor-alpha, fibroblast growth factor and others, affect connexin expression and can alter the Cx43/Cx40 ratio, which may contribute to the formation of an arrhythmogenic substrate. On the other hand, drugs affecting these mediators may influence GJ networking and may thus open new therapeutic horizons.
Jean-Claude Hervé; Stefan Dhein
Related Documents :
12015987 - Oxyr: a molecular code for redox-related signaling.
12963487 - Genistein reduces nf-kappa b in t lymphoma cells via a caspase-mediated cleavage of i k...
7544377 - Activation of nuclear factor-kappa b and gene expression in human endothelial cells by ...
7686747 - Functional nf-kappa b element in rabbit serum amyloid a gene and its role in acute phas...
17027647 - Ese-3 transcription factor is involved in the expression of death receptor (dr)-5 throu...
25376907 - Downy mildew resistant 6 and dmr6-like oxygenase 1 are partially redundant but distinct...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in cardiology     Volume:  42     ISSN:  0065-2326     ISO Abbreviation:  Adv Cardiol     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270063     Medline TA:  Adv Cardiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  107-31     Citation Subset:  IM    
Equipe, Interactions et Communications Cellulaires, IPBC, CNRS-Université de Poitiers, Poitiers, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Communication / physiology
Connexins / drug effects,  metabolism
Down-Regulation / physiology
Gap Junctions / drug effects*,  physiology
Heart / physiology*
Oligopeptides / pharmacology
Up-Regulation / physiology
Reg. No./Substance:
0/AAP 10; 0/Connexins; 0/Oligopeptides; 355151-12-1/rotigaptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Micropatterns of propagation.
Next Document:  Structural and functional coupling of cardiac myocytes and fibroblasts.