Document Detail

Pharmacology of calcium antagonists: clinical relevance in neurology.
MedLine Citation:
PMID:  2180714     Owner:  NLM     Status:  MEDLINE    
Calcium antagonists are of potential value in preventing neuronal death following cerebral ischemia or anoxia. Prevention of calcium influx into neurons, not just preservation of cerebral blood flow, is necessary if these agents are to be protective. To be of value clinically in humans, these agents must be effective even if administered after the ischemic insult has occurred. Experimental studies suggest that flunarizine, which inhibits calcium influx following brain anoxia, prolongs clinical survival and prevents neuronal death even when administered after the ischemic event, has no known significant toxic effects in humans following acute administration, has important potential value in the treatment of stroke, and should be evaluated in controlled clinical trials of patients with acute stroke.
S L Cohan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European neurology     Volume:  30 Suppl 2     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-05-09     Completed Date:  1990-05-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  28-30; discussion 39-41     Citation Subset:  IM    
Department of Neurology, Georgetown University School of Medicine, Washington, D.C.
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MeSH Terms
Brain Ischemia / drug therapy*,  metabolism
Calcium / metabolism,  physiology*
Calcium Channel Blockers / therapeutic use*
Flunarizine / therapeutic use*
Hypoxia, Brain / drug therapy*,  metabolism
Reg. No./Substance:
0/Calcium Channel Blockers; 52468-60-7/Flunarizine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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