| Pharmacology of argatroban. | |
| | |
MedLine Citation:
|
PMID: 21083469 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Argatroban is a synthetic, small-molecule direct thrombin inhibitor that is approved in the USA, the EU and Japan for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT), and for anticoagulation of HIT patients undergoing PCI. Argatroban binds reversibly to, and inhibits both soluble and clot-bound thrombin. Argatroban does not generate antibodies, is not susceptible to degradation by proteases and is cleared hepatically. It has a predictable anticoagulant effect and there is a good correlation between dose, plasma concentration and pharmacodynamic effect. Initial clinical studies suggest that further investigations to establish the use of argatroban in ischemic stroke, acute coronary syndrome, hemodialysis, blood oxygenation, off-pump cardiac surgery and other clinical indications are warranted. |
| | |
Authors:
|
Walter P Jeske; Jawed Fareed; Debra A Hoppensteadt; Bruce Lewis; Jeanine M Walenga |
Related Documents
:
|
17490199 - Ns07 chronic subdural haematomas and anticoagulation or anti-thrombolytic therapy. 19005649 - Evaluation of pulmonary embolism in a pediatric population with high clinical suspicion. 8432749 - The hypercoagulable states. 8124429 - A modified papaverine test and the use of venous constriction in erectile dysfunction. 14687149 - Venous thromboembolism in inflammatory bowel disease. 603279 - Heparin induced thrombocytopenia: eight cases with thrombotic-hemorrhagic complications. 12581239 - Ictal urinary urge: further evidence for lateralization to the nondominant hemisphere. 8911979 - Pharmacokinetic basis for the safety of glimepiride in risk groups of niddm patients. 17908059 - Poststroke urinary incontinence: one-year outcome and relationships with measures of at... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Expert review of hematology Volume: 3 ISSN: 1747-4094 ISO Abbreviation: Expert Rev Hematol Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101485942 Medline TA: Expert Rev Hematol Country: England |
Other Details:
|
Languages: eng Pagination: 527-39 Citation Subset: IM |
Affiliation:
|
Cardiovascular Institute, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA. wjeske@lumc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: part I (Factor Xa...
Next Document: Plasma cell leukemia: concepts and management.