Document Detail


Pharmacology of apolipoprotein A-I.
MedLine Citation:
PMID:  9253539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of HDL and its main protein component the apolipoprotein A-I as being antiatherogenic is well established. Experimental data give support for the involvement of at least three different types of mechanism: (1) the reverse cholesterol transport, (2) anti-inflammatory mechanisms and (3) antithrombotic mechanisms. Depending upon the stage and type of atherosclerosis, different mechanisms may be more or less important. Knowledge of pharmacology of apolipoprotein A-I has strongly increased during past years and clinical studies have started with infusions of apolipoprotein A-I phospholipid complexes.
Authors:
L O Andersson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  8     ISSN:  0957-9672     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Affiliation:
Cardiocon AB, Knivsta, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Anticholesteremic Agents / pharmacology
Anticoagulants / pharmacology
Apolipoprotein A-I / pharmacology*
Arteriosclerosis / metabolism*
Biological Transport
Cholesterol / metabolism
Humans
Lipoproteins, HDL / metabolism*
Phospholipids / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anticholesteremic Agents; 0/Anticoagulants; 0/Apolipoprotein A-I; 0/Lipoproteins, HDL; 0/Phospholipids; 0/apolipoprotein A-I Milano; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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