| Pharmacologically active ellagitannins from Terminalia myriocarpa. | |
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MedLine Citation:
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PMID: 12094296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new ellagitannin, methyl (S)-flavogallonate (14) along with fourteen known compounds, gallic acid, methyl gallate, ethyl gallate, 2,3-di-O-[( S)-4,5,6,4',5',6'-hexahydroxybiphenyl-2,2'-diyldicarbonyl]-(alpha/beta)-D-glucopyranose (4), vitexin, isovitexin, orientin, iso-orientin, kaempferol 3-O-beta-D-rutinoside, rutin, neosaponarin, ellagic acid, flavogallonic acid (13), and (alpha/beta)-punicalagin (15) have been isolated from the leaves of Terminalia myriocarpa Heurck. Protective effect of the major and structurally related compounds 4, 13, 15 and the new compound 14 against CCl 4 -induced hepatotoxicity has been evaluated and compared, using adult male rats weighing 200-250 g. Serum levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lipid peroxide and nitric oxide production were significantly increased by administration of CCl 4 to rats and then reduced significantly only by treatment with compounds 4, 14 and 15 in a dose-dependent manner. Comparison of the protective properties of these compounds showed that compound 14 is more potent than compound 15 than 4 and that compound 13 has a non-significant effect at the used two dose levels. |
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Authors:
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Mohamed S A Marzouk; Sayed A A El-Toumy; Fatma A Moharram; Nagwa M M Shalaby; Amany A E Ahmed |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Planta medica Volume: 68 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-02 Completed Date: 2002-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 523-7 Citation Subset: IM |
Affiliation:
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Chemistry of Tannins and Proteins Department, National Research Centre, Cairo, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood,
drug effects* Animals Antioxidants / pharmacology Aspartate Aminotransferases / blood, drug effects* Carbon Tetrachloride / administration & dosage Hydrolyzable Tannins* Lipid Peroxidation / drug effects Lipid Peroxides / biosynthesis, blood Magnetic Resonance Spectroscopy Male Nitric Oxide / biosynthesis, blood Plant Extracts / chemistry, isolation & purification, pharmacology Plant Leaves / chemistry Rats Rats, Sprague-Dawley Silymarin / pharmacology Tannins / chemistry, isolation & purification, pharmacology* Terminalia* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Hydrolyzable Tannins; 0/Lipid Peroxides; 0/Plant Extracts; 0/Silymarin; 0/Tannins; 0/ellagitannin; 0/methyl-flavogallonate; 10102-43-9/Nitric Oxide; 56-23-5/Carbon Tetrachloride; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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