Document Detail

Pharmacological vitrectomy.
MedLine Citation:
PMID:  10749315     Owner:  NLM     Status:  MEDLINE    
Pharmacological vitrectomy refers to the use of enzymes in an effort to liquefy vitreous and to weaken the adhesion of vitreous cortex to the internal limiting membrane during or before performing vitreous surgery. It is well known that the vitreoretinal interface plays important roles in developing many blinding diseases. To make the vitreous surgery easier for better outcome or to avoid vitrectomy, plasmin, dispase, and chondroinase have been used to promote the disinsersion of vitreous cortex to the internal limiting membrane, a basement membrane of Muller cells. On the other hand, hyaluronidase has been used clinically to facilitate the clearance of vitreous hemorrhage liquefying vitreous body and developing posterior vitreous detachment. This article reviews enzymes as an intraoperative adjunctive agent in vitrectomy.
M Tanaka; H Qui
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in ophthalmology     Volume:  15     ISSN:  0882-0538     ISO Abbreviation:  Semin Ophthalmol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8610759     Medline TA:  Semin Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-61     Citation Subset:  IM    
Department of Ophthalmology, Juntendo University Urayasu Hospital, Japan.
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MeSH Terms
Collagenases / administration & dosage,  therapeutic use
Endopeptidases / administration & dosage,  therapeutic use
Enzymes / administration & dosage,  therapeutic use*
Eye Diseases / drug therapy,  surgery
Fibrinolysin / administration & dosage,  therapeutic use
Fibrinolytic Agents / administration & dosage,  therapeutic use
Hyaluronoglucosaminidase / administration & dosage,  therapeutic use
Retinal Diseases / drug therapy*,  surgery
Treatment Outcome
Vitrectomy / methods*
Vitreous Body / drug effects,  surgery
Reg. No./Substance:
0/Enzymes; 0/Fibrinolytic Agents; EC; EC 3.4.-/Endopeptidases; EC; EC 3.4.24.-/Collagenases; EC 3.4.99.-/dispase

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