| Pharmacological validation of a feline model of steroid-induced ocular hypertension. | |
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MedLine Citation:
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PMID: 10088814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To validate pharmacologically the feline model of steroid-induced ocular hypertension. METHODS: Serial studies were conducted in domesticated adult female cats trained to accept topical ocular drug administration and pneumotonometry. To establish intraocular pressure (IOP) values for each study, measurements were performed at the same time of day for 6 consecutive days. Beginning on day 7, cats received either steroid or vehicle administered topically to both eyes three times a day for approximately 28 days. The IOP measurements were performed daily. RESULTS: After 5 to 7 days of treatment with 0.1% dexamethasone or 1.0% prednisolone acetate, IOP began to increase, reaching peak values within 2 weeks. These values were sustained throughout dosing but declined rapidly to baseline upon cessation of treatment. Maximum IOPs for the dexamethasone- and prednisolone-treated groups averaged 4.5 +/- 0.3 mm Hg (n = 12) greater than the mean IOP value obtained in vehicle-treated cats. Cats treated with 0.25% fluorometholone, 1.0% loteprednol etabonate, and 1.0% rimexolone exhibited increases of 0.6, 1.2, and 1.7 mm Hg, respectively. These values were significantly lower than those observed following treatment with dexamethasone or prednisolone. CONCLUSIONS: The ocular hypertensive effects of selected anti-inflammatory topical ocular steroids in this model are consistent with clinical findings. CLINICAL RELEVANCE: This feline model is a useful tool for assessing the potential IOP liability of novel anti-inflammatory steroids. |
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Authors:
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P Bhattacherjee; C A Paterson; J M Spellman; G Graff; J M Yanni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of ophthalmology Volume: 117 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-03-25 Completed Date: 1999-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 361-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Louisville, KY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Androstadienes / administration & dosage, adverse effects Animals Cats Dexamethasone / administration & dosage, adverse effects Disease Models, Animal* Female Fluorometholone / administration & dosage, adverse effects Glucocorticoids / administration & dosage, adverse effects* Humans Intraocular Pressure / drug effects Ocular Hypertension / chemically induced*, pathology Ophthalmic Solutions / administration & dosage, adverse effects Prednisolone / administration & dosage, adverse effects Pregnadienes / administration & dosage, adverse effects Random Allocation Reproducibility of Results Tonometry, Ocular |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Glucocorticoids; 0/Ophthalmic Solutions; 0/Pregnadienes; 426-13-1/Fluorometholone; 49697-38-3/rimexolone; 50-02-2/Dexamethasone; 50-24-8/Prednisolone; 82034-46-6/loteprednol etabonate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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