| Pharmacological treatment of disruptive behavior in Smith-Magenis syndrome. | |
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MedLine Citation:
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PMID: 20981776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Smith-Magenis syndrome (SMS) is a complex genetic syndrome caused by an interstitial deletion of chromosome 17p11.2. Children and adults with SMS appear to have unique neurobehavioral problems that include: sleep disturbance, self-injurious and maladaptive behaviors, stereotypies, and sensory integration disorders. We gathered retrospective psychotropic use information from parents or other caregivers of 62 individuals with SMS who were asked about use of psychotropic medication from a list of commonly used psychiatric medications. For those drugs identified, respondents were asked to rate the experience with the particular medication using a likert-type scale. Drugs were grouped into seven main categories: (1) stimulants; (2) antidepressants; (3) antipsychotics; (4) sleep aides; (5) mood stabilizers; (6) alpha 2 agonists; and (7) benzodiazepines. Relative frequencies, means and standard deviations pertaining to age and medication effect were derived for each medication category. Six of the seven medication categories examined showed no meaningful deviations from the "no change" score. The benzodiazepine group showed a mild detrimental effect. There were no gender differences in efficacy. Use of psychotropic medication started early in life (mean age 5 years), particularly with sleep aides. Although no medication category was identified as efficacious in SMS, all the categories reported herein may be considered as an option for brief symptomatic relief. |
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Authors:
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Gonzalo Laje; Rebecca Bernert; Rebecca Morse; Maryland Pao; Ann C M Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: American journal of medical genetics. Part C, Seminars in medical genetics Volume: 154C ISSN: 1552-4876 ISO Abbreviation: Am J Med Genet C Semin Med Genet Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-02-18 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101235745 Medline TA: Am J Med Genet C Semin Med Genet Country: United States |
Other Details:
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Languages: eng Pagination: 463-8 Citation Subset: IM |
Affiliation:
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Intramural Research Program at the National Institute of Mental Health, NIH, Bethesda, MD 20892-3719, USA. gonzalo.laje@nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Analysis of Variance Attention Deficit and Disruptive Behavior Disorders / drug therapy*, physiopathology* Child Female Humans Male Psychotropic Drugs / classification, therapeutic use* Questionnaires Retrospective Studies Smith-Magenis Syndrome / physiopathology* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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Z99 MH999999/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Psychotropic Drugs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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