Document Detail

Pharmacological treatment of chronic systolic heart failure: are we scraping the bottom of the barrel?
MedLine Citation:
PMID:  20414119     Owner:  NLM     Status:  MEDLINE    
Heart failure is a major health problem and its prevalence is growing, primarily as a consequence of the aging of the population. Recently, we have witnessed significant progress in reducing the mortality associated with chronic heart failure due to the introduction of renin-angiotensin-aldosterone system inhibitors, beta-blocking agents and the use of electrical devices. However, the prognosis of heart failure is still so disappointing that it remains the leading cause of death in developed countries. This grim record impels the search for new therapeutic strategies. The objective of this paper is to briefly review the results of some recent trials that have been put in place to test the effects of drugs that are deemed to be potentially capable of improving the prognosis of chronic systolic heart failure patients. Despite compelling theoretical premises, the results to date appear to be weak or even disappointing.
Elena Abate; Riccardo Sartor; Claudio Ceconi; Giovanni M Boffa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  11     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-02-11     Revised Date:  2011-06-21    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  893-905     Citation Subset:  IM    
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, via Giustiniani 2, Padua, Italy.
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MeSH Terms
Cardiovascular Agents / therapeutic use*
Chronic Disease
Evidence-Based Medicine
Heart Failure, Systolic / drug therapy*,  mortality
Treatment Outcome
Reg. No./Substance:
0/Cardiovascular Agents
Comment In:
J Cardiovasc Med (Hagerstown). 2011 May;12(5):373   [PMID:  21451336 ]
J Cardiovasc Med (Hagerstown). 2011 Jun;12(6):452   [PMID:  21540677 ]

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