Document Detail


Pharmacological and toxicological activity of Heterophyllaea pustulata anthraquinone extracts.
MedLine Citation:
PMID:  13678245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Benzenic extracts from both stems and leaves of Heterophyllaea pustulata showed the most significant activity in vivo in the Brine Shrimp Lethally Test (BST), relative to others of different polarity. They were therefore selected for in vitro antimicrobial activity studies. Bacteriostatic activity against Micrococcus luteus ATCC 9341 was detected, selectively inhibiting both oxacillin-sensitive and -resistant Staphylococcus aureus, among several gram-positive and gram-negative bacterial species tested. Antifungal activity against important opportunist microorganisms and against those involved in superficial mycosis, all from nosocomial origin was also detected. A chemical screening revealed the presence of anthraquinones as major compounds. Among them, we identified damnacanthal, rubiadin, 2-hydroxy-3-methyl anthraquinone, soranjidiol, rubiadin-1-methyl ether, and damnacanthol in the benzenic stem extract. The benzenic leaf extract shows a similar chemical composition, except for damnacanthal, damnacanthol, soranjidiol-1-methyl ether, and 3 anthraquinones whose structures have not yet been elucidated. Acute toxicity studies revealed a low toxicity in mice for the anthraquinonic extracts, as measured in the LD50 value (123 mg/kg body wt. i.v.), and death was not observed at doses of up to 4000 mg/kg body wt. s.c.
Authors:
S C Nuñez Montoya; A M Agnese; C Pérez; I N Tiraboschi; J L Cabrera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  10     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  569-74     Citation Subset:  IM    
Affiliation:
Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, UNC, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Córdoba, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / administration & dosage,  pharmacology*,  therapeutic use
Antifungal Agents / administration & dosage,  pharmacology*,  therapeutic use
Artemia / drug effects
Gram-Negative Bacteria / drug effects*
Gram-Positive Bacteria / drug effects*
Humans
Lethal Dose 50
Microbial Sensitivity Tests
Mitosporic Fungi / drug effects*
Phytotherapy*
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Plant Leaves
Plant Stems
Rubiaceae*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antifungal Agents; 0/Plant Extracts

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