Document Detail


Pharmacological studies with lincomycin in late pregnancy.
MedLine Citation:
PMID:  4717846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The placental transmission of lincomycin was studied in 60 patients in late pregnancy. A peak maternal blood level of 12.5 mug/ml was recorded 45 minutes after injection, and detectable levels were still present up to 42 hours after a single injection. A peak cord blood level of 2.7 mug/ml was recorded 55 minutes after injection; cord blood levels were about a quarter of the maternal blood levels, and in most cases no levels were detectable 24 hours after a single injection. The passage of lincomycin into and out of the liquor was slower and more variable, but some hours after injection the liquor levels were always higher than the maternal or cord blood levels, and detectable levels were still present in the liquor 52 hours after a single injection. Repeated injections did not lead to any significant accumulation of lincomycin. The only side effect was a possible case of neuromuscular block in a mother delivered by caesarean section. No infant was adversely affected.
Authors:
N M Duignan; J Andrews; J D Williams
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  3     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1973 Jul 
Date Detail:
Created Date:  1973-09-13     Completed Date:  1973-09-13     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid
Cesarean Section
Female
Humans
Injections
Lincomycin / administration & dosage,  adverse effects,  blood,  metabolism*,  pharmacology
Maternal-Fetal Exchange*
Neuromuscular Depolarizing Agents
Placenta / metabolism
Pregnancy*
Time Factors
Twins
Umbilical Cord
Chemical
Reg. No./Substance:
0/Neuromuscular Depolarizing Agents; 154-21-2/Lincomycin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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