Document Detail

Pharmacological studies of arrhythmias induced by rose bengal photoactivation.
MedLine Citation:
PMID:  1649784     Owner:  NLM     Status:  MEDLINE    
Singlet oxygen and superoxide production by rose bengal photoactivation leads to rapid electrophysiological changes and arrhythmias. To investigate which intermediate is causative and to probe possible mechanisms, hearts (n = at least 6/group) were perfused aerobically for 10 min without rose bengal followed by 5 min with rose bengal before illumination for 20 min. In controls, all or most hearts exhibited ventricular premature beats, ventricular tachycardia, and complete atrioventricular block. Most antioxidants tested had no protective effect; histidine, however, significantly delayed the onset of electrocardiographic (ECG) changes. In further studies, two antiarrhythmic agents (quinidine and verapamil) had no little protective effect, whereas R56865 significantly delayed the onset of ECG changes and reduced the incidence of arrhythmias. However, spectrophotometric and laser pulse radiolysis studies showed that this apparent protective effect might have resulted from an interaction between R56865 and the rose bengal molecule, leading to a reduction in singlet oxygen production. In conclusion, the electrophysiological changes induced by rose bengal photoactivation are likely to be due to singlet oxygen; antiarrhythmic drugs appear to be unable to protect against the injury unless there is some interaction with the photoactivation process.
M Bernier; Y Kusama; M Borgers; L Ver Donck; O Valdes-Aguilera; D C Neckers; D J Hearse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  10     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-28     Completed Date:  1991-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-96     Citation Subset:  IM; S    
Cardiovascular Research, Rayne Institute, St. Thomas' Hospital, London, U.K.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced*,  drug therapy
Coronary Circulation / drug effects
Free Radicals
Heart Rate / drug effects
Oxygen / toxicity
Piperidines / pharmacology
Rats, Inbred Strains
Rose Bengal / toxicity*
Superoxides / toxicity
Thiazoles / pharmacology
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Benzothiazoles; 0/Free Radicals; 0/Piperidines; 0/Thiazoles; 104606-13-5/R 56865; 11062-77-4/Superoxides; 11121-48-5/Rose Bengal; 7782-44-7/Oxygen

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