Document Detail


Pharmacological stimulation of arterial chemoreceptors in conscious rats produces differential responses in renal cortical and medullary blood flow.
MedLine Citation:
PMID:  9673424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. There have been no previously published data regarding intrarenal blood flow distribution in acute whole-body hypoxic hypoxia and/or arterial chemoreceptor stimulation in normoxic mammals. 2. Cortical and medullary blood flows were measured simultaneously before and in response to pharmacological stimulation of peripheral arterial chemoreceptors by i.v. injection of almitrine bismesylate (0.25 mg/kg). 3. Arterial chemoreceptor excitation reduced cortical blood flow but only in innervated kidneys. An effect on medullary blood flow was observed in neither innervated nor denervated kidneys. 4. These data indicate that renal cortical and medullary blood flows react differently to arterial chemoreceptor stimulation.
Authors:
C Ledderhos; V Gross; A W Cowley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  25     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-09     Completed Date:  1998-10-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  536-40     Citation Subset:  IM    
Affiliation:
Institute of Physiology, Ernst-Moritz-Arndt-University, Greifswald, Germany. honig@rz.uni-greifswald.de
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MeSH Terms
Descriptor/Qualifier:
Almitrine / pharmacology
Animals
Arteries / drug effects*
Blood Pressure / drug effects
Chemoreceptor Cells / drug effects*
Denervation
Heart Rate / drug effects
Kidney / innervation
Kidney Cortex / drug effects*
Kidney Medulla / drug effects*
Male
Norepinephrine / pharmacology
Rats
Rats, Sprague-Dawley
Renal Circulation / drug effects
Respiratory System Agents / pharmacology
Stimulation, Chemical
Vasoconstrictor Agents / pharmacology
Grant Support
ID/Acronym/Agency:
HL-29587/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Respiratory System Agents; 0/Vasoconstrictor Agents; 27469-53-0/Almitrine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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