Document Detail

Pharmacological screening of bryophyte extracts that inhibit growth and induce abnormal phenotypes in human HeLa cancer cells.
MedLine Citation:
PMID:  19709324     Owner:  NLM     Status:  MEDLINE    
Antitumor activities of substances from natural sources apart from vascular plants and micro-organisms have been poorly investigated. Here we report on a pharmacological screening of a bryophyte extract library using a phenotypic cell-based assay revealing microtubules, centrosomes and DNA. Among the 219 moss extracts tested, we identified 41 extracts acting on cell division with various combinations of significant effects on interphasic and mitotic cells. Seven extracts were further studied using a cell viability assay, cell cycle analysis and the phenotypic assay. Three distinct pharmacological patterns were identified including two unusual phenotypes.
Lucie Krzaczkowski; Michel Wright; Delphine Rebérioux; Georges Massiot; Chantal Etiévant; Jean Edouard Gairin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  23     ISSN:  1472-8206     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-27     Completed Date:  2009-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  473-82     Citation Subset:  IM    
Centre de Recherche en Pharmacologie approximately Santé, UMR 2587 CNRS-Pierre Fabre, ISTMT, 31432 Toulouse, Cedex 4, France.
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MeSH Terms
Adenocarcinoma / drug therapy,  pathology
Antineoplastic Agents, Phytogenic / pharmacology*
Bryophyta / chemistry*
Cell Cycle / drug effects
Cell Survival / drug effects
Centrosome / drug effects,  metabolism
DNA / drug effects,  metabolism
Drug Screening Assays, Antitumor
Hela Cells
Microtubules / drug effects,  metabolism
Plant Extracts / pharmacology*
Uterine Cervical Neoplasms / drug therapy*,  pathology
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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