Document Detail

Pharmacological reduction of the systemically damaging effects of local ischaemia.
MedLine Citation:
PMID:  8181617     Owner:  NLM     Status:  MEDLINE    
Many patients with intermittent claudication are encouraged to exercise. However, transient exercise-induced muscle ischaemia results in systemic vascular endothelial injury associated with increased vascular permeability manifest as an increase in urinary albumin excretion. Repetitive systemic vascular endothelial injury leads to accelerated atherogenesis and may explain the high cardiovascular mortality rate of claudicants. Oxpentifylline, a haemorheological agent, has recently been shown to prevent vascular endothelial injury in animal models. A double-blind, placebo-controlled, cross-over trial was undertaken to determine the effect of oxpentifylline on exercise-induced systemic vascular endothelial injury in 20 claudicants. Urinary albumin, expressed as a creatinine ratio (ACR), was measured before and 1 and 2 hours after standardised exercise following 1 week treatment with either active drug or placebo. Oxpentifylline reduced the median (range) 1 hour post exercise increase in ACR from 0.35 (-0.46-12.72) to 0.02 (-6.00-14.10) mg/mmol. (p = 0.030, z = 2.2 Wilcoxon rank sign test). These results confirm that local ischaemia is associated with a potentially deleterious systemic effect and that it may be possible to attenuate this pharmacologically. The clinical significance of this is yet to be determined.
G M Tsang; K Sanghera; P Gosling; F C Smith; I S Paterson; M H Simms; C P Shearman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of vascular surgery     Volume:  8     ISSN:  0950-821X     ISO Abbreviation:  Eur J Vasc Surg     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-16     Completed Date:  1994-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709440     Medline TA:  Eur J Vasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Department of Surgery, Queen Elizabeth Hospital, Birmingham, U.K.
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MeSH Terms
Albuminuria / diagnosis
Capillary Permeability / drug effects
Double-Blind Method
Exercise Test
Exercise Tolerance / drug effects
Intermittent Claudication / drug therapy*,  physiopathology
Leg / blood supply
Pentoxifylline / therapeutic use*
Reperfusion Injury / drug therapy,  physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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