| Pharmacological profile of valsartan, a non-peptide angiotensin II type 1 receptor antagonist. 4th communication: improvement of heart failure of rats with myocardial infarction by valasartan. | |
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MedLine Citation:
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PMID: 9205776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hemodynamic effects of valsartan ((S)-N-valeryl-N-¿[2'-(1H-tetrazol-5-yl)bipheneoyl-4-yl]meth yl¿valine, CAS 137862-53-4, CGP 48933), a new angiotensin II type 1 receptor antagonist, on rats with myocardial infarction induced by coronary artery ligation was examined. Four weeks after ligation, mean blood pressure, left ventricular pressure and cardiac output decreased, while left ventricular end-diastolic pressure increased in control rats. Left ventricular end-diastolic pressure significantly decreased in rats treated with valsartan at 30 mg/kg/d p.o. for 4 weeks. Total systemic resistance remarkably decreased in those with enalapril 3 mg/kg/d p.o. and valsartan 30 mg/kg/d p.o. Valsartan and enalaprilat did not affect cardiac functions of isolated intact rat hearts before and after ischemia in Langendorff apparatus. In addition to hemodynamic effects observed in vivo, valsartan at 30 mg/kg p.o. significantly inhibited left ventricular hypertrophy. Valsartan would thus appear to be clinically useful for treating heart failure following myocardial infarction. |
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Authors:
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N Hayashi; Y Fujimura; S Yamamoto; M Kometani; K Nakao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 47 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-13 Completed Date: 1997-08-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 625-9 Citation Subset: IM |
Affiliation:
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Drug Discovery Research Unit, Ciba-Geigy Japan Ltd., Takarazuka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology, therapeutic use* Blood Pressure / drug effects Body Weight / drug effects Cardiomegaly / physiopathology Enalapril / pharmacology, therapeutic use Male Myocardial Infarction / physiopathology* Myocardial Ischemia / drug therapy* Myocardial Reperfusion Injury / physiopathology Organ Size / drug effects Rats Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin / antagonists & inhibitors* Tetrazoles / pharmacology, therapeutic use* Valine / analogs & derivatives*, pharmacology, therapeutic use Vascular Resistance / drug effects Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Angiotensin, Type 2; 0/Receptors, Angiotensin; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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