| Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content. | |
| | |
MedLine Citation:
|
PMID: 20566435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production. This study was to investigate the effects of pre-ischemic pharmacological preconditioning (PC) with L-carnitine (L-Car) on myocardial infarct size and cardiac functions in ischemic and reperfused isolated rat heart and meanwhile on left ventricular glycogen and lactate content. Isolated rat hearts were subjected to 30 min coronary artery occlusion followed by 120 min reperfusion. The hearts (n= 8-12) were perfused with L-Car (0.5-5 mM) only for 15 min before to 10 min after induction of ischemia. Preconditioning of the hearts with L-Car provided concentration-dependent cardioprotection as evidenced by improved postischemic ventricular functional recovery (developed pressure, left ventricular end diastolic pressure and coronary flow rate) and reduced myocardial infarct size (p<0.001). L-Car (2.5 mM) decreased both glycogen (p<0.001) and lactate (p>0.05) content in left ventricle during ischemia compared with the control. The results of this study demonstrate that L-Car pharmacologically precondition the hearts against ischemic and reperfusion injury in part by recovery of postischemic ventricular hemodynamic functions, depletion of glycogen and therefore reduction of lactate accumulation. |
| | |
Authors:
|
Moslem Najafi; Ali Javidnia; Amir Ghorbani-Haghjo; Sadollah Mohammadi; Alireza Garjani |
Related Documents
:
|
12124205 - Contractility and ischemic response of hearts from transgenic mice with altered sarcole... 10226865 - Role of angiotensin in cardioprotective effect of ischemic preconditioning. 12731455 - Selective mitochondrial katp channel activation by nicorandil and 3-pyridyl pinacidil r... 11404145 - L-arginine given after ischaemic preconditioning can enhance cardioprotection in isolat... 12124205 - Contractility and ischemic response of hearts from transgenic mice with altered sarcole... 1948115 - Pharmacological stress with adenosine for myocardial perfusion imaging. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pakistan journal of pharmaceutical sciences Volume: 23 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-22 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
|
Languages: eng Pagination: 250-5 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
biosynthesis Animals Carnitine / pharmacology* Glycogen / analysis* Hemodynamics / drug effects* Ischemic Preconditioning, Myocardial* Lactic Acid / analysis* Male Myocardial Ischemia / drug therapy, physiopathology Myocardial Reperfusion Injury / prevention & control Myocardium / metabolism* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
50-21-5/Lactic Acid; 541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antimicrobial susceptibility testing of newer quinolones against gram positive and gram negative cli...
Next Document: Analgesic and antiinflammatory activity of methanolic extract of Acalypha indica Linn.