Document Detail


Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content.
MedLine Citation:
PMID:  20566435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production. This study was to investigate the effects of pre-ischemic pharmacological preconditioning (PC) with L-carnitine (L-Car) on myocardial infarct size and cardiac functions in ischemic and reperfused isolated rat heart and meanwhile on left ventricular glycogen and lactate content. Isolated rat hearts were subjected to 30 min coronary artery occlusion followed by 120 min reperfusion. The hearts (n= 8-12) were perfused with L-Car (0.5-5 mM) only for 15 min before to 10 min after induction of ischemia. Preconditioning of the hearts with L-Car provided concentration-dependent cardioprotection as evidenced by improved postischemic ventricular functional recovery (developed pressure, left ventricular end diastolic pressure and coronary flow rate) and reduced myocardial infarct size (p<0.001). L-Car (2.5 mM) decreased both glycogen (p<0.001) and lactate (p>0.05) content in left ventricle during ischemia compared with the control. The results of this study demonstrate that L-Car pharmacologically precondition the hearts against ischemic and reperfusion injury in part by recovery of postischemic ventricular hemodynamic functions, depletion of glycogen and therefore reduction of lactate accumulation.
Authors:
Moslem Najafi; Ali Javidnia; Amir Ghorbani-Haghjo; Sadollah Mohammadi; Alireza Garjani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pakistan journal of pharmaceutical sciences     Volume:  23     ISSN:  1011-601X     ISO Abbreviation:  Pak J Pharm Sci     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426356     Medline TA:  Pak J Pharm Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / biosynthesis
Animals
Carnitine / pharmacology*
Glycogen / analysis*
Hemodynamics / drug effects*
Ischemic Preconditioning, Myocardial*
Lactic Acid / analysis*
Male
Myocardial Ischemia / drug therapy,  physiopathology
Myocardial Reperfusion Injury / prevention & control
Myocardium / metabolism*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid; 541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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