Document Detail


Pharmacological perspectives on the detoxification of plant secondary metabolites: implications for ingestive behavior of herbivores.
MedLine Citation:
PMID:  16770714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plant secondary metabolites (PSMs) are a major constraint to the ingestion of food by folivorous and browsing herbivores. Understanding the way in which mammalian detoxification pathways are adapted to deal with PSMs is crucial to understanding how PSMs influence ingestive behavior of herbivores and hence their fitness and the impact that they have on vegetation. Pharmacological concepts can provide insights into the relationship between the absorption and metabolic fate of PSMs and ingestive behavior. Lipophilic PSMs will be absorbed into the bloodstream and must be removed fast enough to prevent their accumulation to toxic levels. Elimination depends on their metabolism, usually by cytochrome P450 enzymes, to more polar metabolites that can be excreted by the kidney. The concentration of PSM in blood (C) is a better measure of exposure to a toxin compared to the amount ingested because there can be great variability in the rate and degree of absorption from the gut. C rises and falls depending on the relative rates of absorption and elimination. These rates depend in part on metabolic and transport processes that are saturable and liable to inhibition and induction by PSMs, indicating that complex interactions are likely. Herbivores can use diet choice and the rate and amount of PSM consumption to prevent C from reaching a critical level that produces significant adverse effects.
Authors:
Stuart McLean; Alan J Duncan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-05-23
Journal Detail:
Title:  Journal of chemical ecology     Volume:  32     ISSN:  0098-0331     ISO Abbreviation:  J. Chem. Ecol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505563     Medline TA:  J Chem Ecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1213-28     Citation Subset:  IM    
Affiliation:
School of Pharmacy, University of Tasmania, Churchill Avenue, Sandy Bay Hobart, Australia. stuart.mclean@utas.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Feeding Behavior*
Pharmacokinetics
Plants / metabolism*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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