Document Detail

Pharmacological outcomes in older people with newly diagnosed epilepsy.
MedLine Citation:
PMID:  16388987     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Old age is the most common time in life to develop epilepsy. Despite this, there are few published data exploring pharmacological outcomes in this population. METHODS: We analyzed outcomes in 117 older patients (median age, 73; range, 65-92) for whom localization-related epilepsy was newly diagnosed and treatment begun at a single center over a 20-year period. RESULTS: Seventy-three (62%) patients became seizure-free for at least 12 months on their first AED, with 30 (26%) failing to respond and 14 (12%) not tolerating the treatment. Following pharmacological manipulation, 93 (79%) patients attained remission, 87 (93%) on monotherapy and 6 (7%) on duotherapy. No individual AED was more likely to confer seizure freedom than any other. Patients attaining remission were more likely to have had fewer pretreatment seizures (P=0.0078) than those who did not obtain full seizure control. CONCLUSION: The prognosis in epilepsy may be better in older than younger people, perhaps reflecting lower lesional epileptogenicity and genetic predisposition.
Linda J Stephen; Kevin Kelly; Rajiv Mohanraj; Martin J Brodie
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Publication Detail:
Type:  Journal Article     Date:  2006-01-04
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  8     ISSN:  1525-5050     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-7     Citation Subset:  IM    
Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK.
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MeSH Terms
Age Factors
Age of Onset
Aged, 80 and over
Anticonvulsants / therapeutic use*
Epilepsies, Partial / drug therapy*,  epidemiology
Remission Induction
Retrospective Studies
Treatment Outcome
Reg. No./Substance:

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