| Pharmacological options for inducing maximal hyperaemia during studies of coronary physiology. | |
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MedLine Citation:
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PMID: 18327838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The coronary pressure wire is used for physiological assessment of the coronary vasculature increasingly frequently in clinical practice. Fractional flow reserve (FFR) can now be used to assess lesion severity in a variety of anatomical situations. Increasingly, the coronary pressure wire is being used to interrogate the coronary microvasculature. Coronary flow reserve (CFR) and Index of microcirculatory resistance (IMR) require hyperaemia to accurately assess thermodilution-derived mean transit times, and pressure derived collateral flow index (CFIp) is calculated from coronary wedge pressure and aortic pressure at hyperaemia. In addition, coronary flow velocity as assessed by a coronary Doppler flow wire needs appropriate induction of hyperaemia. However, the majority of this article will however focus on hyperaemia induction for pressure wire studies particularly FFR. Significant clinical decisions are made as a result of FFR readings, therefore it is imperative that they are carried out correctly. Maximal coronary hyperaemia is essential in producing accurate, reproducible measurements. This article focuses on the pharmacological agents that can be used for this purpose, discusses which agents can be used in specific situations, and briefly addresses the future of pharmacological stress in the catheter laboratory. |
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Authors:
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Ross J McGeoch; Keith G Oldroyd |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 71 ISSN: 1522-726X ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-10 Completed Date: 2008-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 198-204 Citation Subset: IM |
Copyright Information:
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Copyright 2008 Wiley-Liss, Inc. |
Affiliation:
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Department of Cardiology, Western Infirmary, Glasgow, United Kingdom. rossmcgeoch@doctors.net.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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administration & dosage Adenosine Triphosphate / pharmacology Animals Caffeine / pharmacology Coronary Stenosis / diagnosis, physiopathology* Dobutamine / pharmacology Fractional Flow Reserve, Myocardial / drug effects*, physiology Humans Hyperemia / chemically induced* Infusions, Intravenous Nitroprusside / pharmacology Papaverine / pharmacology Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 34368-04-2/Dobutamine; 56-65-5/Adenosine Triphosphate; 58-08-2/Caffeine; 58-61-7/Adenosine; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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