Document Detail

Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.
MedLine Citation:
PMID:  2992662     Owner:  NLM     Status:  MEDLINE    
Arachidonic acid (AA) was used to induce contractions of guinea-pig tracheal and lung parenchymal preparations in the presence of indomethacin. Prior addition of FPL55712, nordihydroguaiaretic acid (NDGA), piriprost, benoxaprofen or nafazatrom, in order of potency, inhibited AA-induced contractions of trachea. Higher concentrations (2 - 3 fold) were necessary to inhibit contractions of parenchyma. FPL55712 and piriprost appeared to act as pharmacological antagonists of leukotrienes because they rapidly reduced the tone of the airways established by AA. Administration of exogenous AA to indomethacin-treated trachea appears to be a good model to examine leukotriene receptor antagonists and inhibitors of the lipoxygenase pathway.
J F Burka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  85     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-10-17     Completed Date:  1985-10-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
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MeSH Terms
Arachidonate Lipoxygenases
Arachidonic Acid
Arachidonic Acids / antagonists & inhibitors*,  pharmacology
Catechols / pharmacology
Chromones / pharmacology
Epoprostenol / pharmacology
Guinea Pigs
Indomethacin / pharmacology
Lipoxygenase Inhibitors*
Lung / physiology*
Muscle Contraction / drug effects*
Nordihydroguaiaretic Acid
Propionic Acids / pharmacology
Pyrazoles / pharmacology
Receptors, Leukotriene
Receptors, Prostaglandin / drug effects,  physiology
Trachea / physiology*
Reg. No./Substance:
0/Arachidonic Acids; 0/Catechols; 0/Chromones; 0/Lipoxygenase Inhibitors; 0/Propionic Acids; 0/Pyrazoles; 0/Pyrazolones; 0/Receptors, Leukotriene; 0/Receptors, Prostaglandin; 35121-78-9/Epoprostenol; 40786-08-1/FPL 55712; 500-38-9/Nordihydroguaiaretic Acid; 506-32-1/Arachidonic Acid; 51234-28-7/benoxaprofen; 53-86-1/Indomethacin; 59040-30-1/nafazatrom; 79672-88-1/piriprost; EC 1.13.11.-/Arachidonate Lipoxygenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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