Document Detail

Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning.
MedLine Citation:
PMID:  11337029     Owner:  NLM     Status:  MEDLINE    
The term "ischemic preconditioning (PC)" was first applied to canine myocardium subjected to brief episodes of ischemia and reperfusion that tolerated a more prolonged episode of ischemia better than myocardium not previously exposed to ischemia. Protective effect of myocardial ischemic PC was demonstrated in several animal species, resulting in the strongest endogenous form of protection against myocardial injury, jeopardized myocardium, infarct size, and arrhythmias other than early reperfusion. New onset angina before acute myocardial infarction, episodes of myocardial ischemia during coronary angioplasty or bypass surgery, and the "warm-up" phenomenon may represent clinical counterparts of the PC phenomenon in humans. Here, we have attempted to summarize pharmacological modulation, preclinical studies, and new clinical features of ischemic PC. To date, the pathophysiological basis of the "chemical PC" is still not well established, and "putting PC in a bottle" for clinical applications still remains a new pharmacological venture.
C Napoli; A Pinto; G Cirino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  88     ISSN:  0163-7258     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-05-07     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-31     Citation Subset:  IM    
Department of Medicine, Federico II University of Naples, P.O. Box, Naples 80131, Italy.
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MeSH Terms
Angina Pectoris / physiopathology
Blood Glucose
Coronary Artery Bypass
Disease Models, Animal
Drug Therapy / trends
Ischemic Preconditioning, Myocardial*
Middle Aged
Myocardial Ischemia / drug therapy,  physiopathology*
Receptors, Opioid / physiology
Receptors, Purinergic P1 / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Receptors, Opioid; 0/Receptors, Purinergic P1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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