Document Detail


Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs.
MedLine Citation:
PMID:  6173476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In dogs anesthetized with pentobarbital, 60 min local i.a. infusions of prostaglandin E1 (4 micrograms/min) together with bradykinin (10 micrograms base/min) into forelimbs perfused at a constant pump controlled flow rate produced decreases in perfusion pressure and very marked increases in lymph flow, lymph total protein concentration, total protein transport and weight (266 g). Pretreatment with indomethacin did not significantly reduce the very marked increases in these parameters produced by the combined prostaglandin E1-bradykinin infusions. Treatment with diphenhydramine completely prevented the increases in lymph flow, lymph total protein concentration, total protein transport, weight and vasodilation produced by infusions of histamine, but not those produced by infusions of prostaglandin E1 or bradykinin. Pretreatment with methylprednisolone prevented the increases in lymph flow, lymph total protein concentration, total protein transport and weight produced by infusions of prostaglandin E1, but not those produced by infusions of high doses of histamine or bradykinin. Treatment with either methylprednisolone or diphenhydramine significantly reduced the very marked increases in these parameters produced by combined infusions of prostaglandin E1 and bradykinin to levels produced by infusions of bradykinin alone. Vasopressin or isoproterenol treatment essentially prevented the very marked increases in lymph flow, lymph total protein concentration, total protein transport and weight produced by combined infusions of prostaglandin E1 and bradykinin. These data suggest that the potentiation of the bradykinin edema formation produced by prostaglandin E1 results from an endogenous release of histamine and that treatment with vasopressin or isoproterenol essentially prevents the development of edema produced by combined infusions of these autacoids. Moreover, the potentiation is not dependent on the vasodilator action of prostaglandin E1 as it may be demonstrated under constant controlled flow conditions.
Authors:
C M Prasad; S W Adamski; E Svensjö; G J Grega
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  220     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alprostadil
Animals
Bradykinin / pharmacology*
Diphenhydramine / pharmacology
Dogs
Drug Synergism
Edema / chemically induced*,  physiopathology
Female
Forelimb / blood supply
Histamine Release / drug effects
Indomethacin / pharmacology
Infusions, Intra-Arterial
Isoproterenol / pharmacology
Male
Methylprednisolone / pharmacology
Prostaglandins E / pharmacology*
Vasodilation / drug effects*
Vasopressins / pharmacology
Grant Support
ID/Acronym/Agency:
HL25257/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins E; 11000-17-2/Vasopressins; 53-86-1/Indomethacin; 58-73-1/Diphenhydramine; 58-82-2/Bradykinin; 745-65-3/Alprostadil; 7683-59-2/Isoproterenol; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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