| Pharmacological manipulation of peripheral resistance during distal vascular reconstruction. | |
| | |
MedLine Citation:
|
PMID: 1382323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A randomised placebo-controlled trial was conducted to investigate the effects of iloprost, a stable prostacyclin analogue, on peripheral resistance, during femoro-crural arterial bypass. 3000 ng of iloprost, infused into the graft, produced an immediate drop in peripheral resistance by a mean (range) of 43% (4-80%; p less than 0.01, Wilcoxon). Decreased peripheral resistance persisted to 20 minutes. Graft flow during the same period increased by 59.8% (-7 to 294%; p less than 0.01) and this increase persisted after the operation. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period. |
| | |
Authors:
|
F C Smith; C P Shearman |
Related Documents
:
|
3490333 - Comparison of perioperative and postoperative phasic blood flow in aortocoronary venous... 10424373 - Comparative of blood flow to the ankle-brachial index after iliac angioplasty. 22294473 - C reactive protein: impact on peripheral tissue oxygenation and perfusion in neonates. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: VASA. Supplementum Volume: 36 ISSN: 0251-1029 ISO Abbreviation: Vasa Suppl Publication Date: 1992 |
Date Detail:
|
Created Date: 1992-10-22 Completed Date: 1992-10-22 Revised Date: 2008-02-21 |
Medline Journal Info:
|
Nlm Unique ID: 8704474 Medline TA: Vasa Suppl Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 55-7 Citation Subset: IM |
Affiliation:
|
University Department of Vascular Surgery, Queen Elizabeth Hospital, Birmingham, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Blood Flow Velocity / physiology Combined Modality Therapy Female Foot / blood supply* Graft Occlusion, Vascular / physiopathology Humans Iloprost / administration & dosage* Ischemia / physiopathology, surgery* Male Middle Aged Saphenous Vein / transplantation* Vascular Resistance / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of mepartricin on the growth of hypertrophic prostatic tissue in primary culture. Creation o...
Next Document: Dimethylnitrosamine (DMN)-induced IL-1 beta, TNF-alpha, and IL-6 inflammatory cytokine expression.