| Pharmacological magnetic resonance imaging: a new application for functional MRI. | |
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MedLine Citation:
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PMID: 10918638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various methods, including functional magnetic resonance imaging (fMRI), have recently been developed to allow investigators to study functional activity in the living brain. Such techniques are now being used to investigate regionally specific brain activity associated with the administration of CNS-active drugs. fMRI in particular is increasingly recognized as being a relatively non-invasive way to perform pharmacological investigations in experimental animals, healthy human volunteers, and individuals with CNS disease. This use of fMRI, dubbed 'pharmacological MRI' or 'phMRI', holds the promise of providing relatively straightforward pharmacodynamic assays and can be used to establish brain-penetrability parameters, or dose-ranging information for novel therapeutic compounds. |
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Authors:
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R A Leslie; M F James |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in pharmacological sciences Volume: 21 ISSN: 0165-6147 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-01 Completed Date: 2000-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 314-8 Citation Subset: IM |
Affiliation:
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Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (North), Third Avenue, Harlow, Essex, UK CM19 5AW. ron_leslie-1@sbphrd.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics
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pharmacology Animals Brain / drug effects, physiology* Humans Magnetic Resonance Imaging* Oxygen / blood |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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Trends Pharmacol Sci. 2000 Nov;21(11):422-3
[PMID:
11126373
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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