| Pharmacological issues relating to viral resistance. | |
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MedLine Citation:
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PMID: 10885828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anti-HIV drug regimens can fail for a number of reasons including virological resistance, difficulties of adherence and poor tolerability. However, this brief review focuses on the development of "pharmacological" resistance as an area of great importance in drug failure. For nucleoside reverse transcriptase inhibitors (NRTIs) this is related to the possible down-regulation of the intracellular phosphorylation of an NRTI with time. For protease inhibitors the concern is cells expressing transmembrane energy-dependent transporters (such as p-glycoprotein, p-gp; or multi-drug resistance protein, MRP) which efflux drug (particularly protease inhibitors) out of the cell so that intracellular concentrations of drug are insufficient for antiviral effect. |
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Authors:
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D J Back |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Infection Volume: 27 Suppl 2 ISSN: 0300-8126 ISO Abbreviation: Infection Publication Date: 1999 |
Date Detail:
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Created Date: 2000-07-27 Completed Date: 2000-07-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0365307 Medline TA: Infection Country: GERMANY |
Other Details:
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Languages: eng Pagination: S42-4 Citation Subset: IM; X |
Affiliation:
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Dept. of Pharmacology and Therapeutics, University of Liverpool, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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pharmacology* Drug Resistance, Microbial / physiology* HIV Infections / drug therapy Humans Phosphorylation / drug effects Treatment Failure Virus Physiological Phenomena / drug effects* Viruses / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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