| Pharmacological inhibition of leukotriene biosynthesis: effects on the heart conductance. | |
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MedLine Citation:
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PMID: 20228415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukotrienes are lipid mediators produced via 5-lipooxygenase pathway of arachidonic acid. At least two cysteinyl-leukotrienes receptors are highly expressed in the heart, including the conduction system. Coronary angiography or angioplasty is accompanied by release of cysteinyl leukotrienes into coronary circulation and into urine. We tested the hypothesis that inhibition of leukotrienes biosynthesis would affect the conductance system function. In a double-blind placebo controlled study, patients with stable angina undergoing elective coronary catheterization or angioplasty were randomly assigned to 48 hrs treatment with a 5-lipoxgenase inhibitor (n=54) or placebo (n=49). ECG Holter recording was carried out for 24 hrs before and after the procedure and urinary leukotriene E(4) measurements were done. Inhibition of 5-lipoxygenase caused 26% reduction of urinary leukotriene E(4), associated with: 1) decrease in heart rate by about 7%, 2) enhanced heart rate variability; 3) protection against depressions in atrioventricular conductance and ventricular repolarization induced by the procedure. No effects on either arrhythmias, or ECG patterns of ischemia were noted. We conclude that pharmacological inhibition of 5-lipoxygenase, shortly before percutaneous coronary intervention, reveals specific actions of leukotrienes on the heart rhythm. Inhibitors of 5-lipoxygenase might be of interest as a novel class of cardiac drugs affecting the conductive system. |
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Authors:
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M Sanak; J Dropinski; B Sokolowska; J Faber; M Rzeszutko; A Szczeklik |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 61 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Jagiellonian University Medical College, Cracow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina, Unstable / drug therapy, enzymology, urine Arachidonate 5-Lipoxygenase / antagonists & inhibitors, biosynthesis Double-Blind Method Female Heart Conduction System / drug effects*, enzymology Heart Rate / drug effects*, physiology* Humans Leukotriene Antagonists / pharmacology* Leukotriene E4 / antagonists & inhibitors, biosynthesis, urine Leukotrienes* / biosynthesis, metabolism, physiology Lipoxygenase Inhibitors / pharmacology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Leukotriene Antagonists; 0/Leukotrienes; 0/Lipoxygenase Inhibitors; 75715-89-8/Leukotriene E4; EC 1.13.11.34/Arachidonate 5-Lipoxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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