| Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin. | |
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MedLine Citation:
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PMID: 20868234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renin is the first enzyme in the renin-angiotensin-aldosterone system which is the principal regulator of blood pressure and hydroelectrolyte balance. Previous studies suggest that cathepsin B is the activator of the prorenin zymogen. Here, we show no difference in plasma renin activity, or mean arterial blood pressure between wild-type and cathepsin B knockout mice. To account for potential gene compensation, a potent, selective, reversible cathepsin B inhibitor was developed to determine the role of cathepsin B on prorenin processing in rats. Pharmacological inhibition of cathepsin B in spontaneously hypertensive and double transgenic rats did not result in a reduction in renal mature renin protein levels or plasma renin activity. We conclude that cathepsin B does not play a significant role in this process in rodents. |
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Authors:
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M David Percival; Sylvie Toulmond; Nathalie Coulombe; Wanda Cromlish; Sylvie Desmarais; Susana Liu; René St-Jacques; Jacques Yves Gauthier; Jean-Francois Fournier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological chemistry Volume: 391 ISSN: 1437-4315 ISO Abbreviation: Biol. Chem. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-03-14 Revised Date: 2012-09-17 |
Medline Journal Info:
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Nlm Unique ID: 9700112 Medline TA: Biol Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 1469-73 Citation Subset: IM |
Affiliation:
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Department of In Vitro Sciences, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada. dave_percival@merck.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cathepsin B / antagonists & inhibitors, genetics, physiology* Enzyme Inhibitors / pharmacology Hypertension / genetics, metabolism Mice Mice, Knockout Rats Rats, Transgenic Renin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; EC 3.4.22.1/Cathepsin B; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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