| Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers. | |
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MedLine Citation:
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PMID: 19219759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The infusion of flowers of several species of Citrus genera is used as a sedative to treat insomnia in Mexican traditional medicine. The aims of this study were to investigate the sedative effect of different extracts of flowers of Citrus sinensis (L.) Osbeck (Rutaceae) and describe the pharmacological action mechanism of the sedative active compounds of this plant. The methanol and dichloromethane extracts, obtained from the flowers of Citrus sinensis (L.) Osbeck (Rutaceae), showed a dose-dependent sedative effect in the exploratory cylinder model in mice, with ED50 (ip) values of 47.04+/-12.03 mg/kg and 129.15+/-21.25 mg/kg, respectively. Hesperidin (ED50=11.34+/-2.48 mg/kg) was identified in the methanol extract as the sedative active principle of this plant. The pre-treatment with atropine (1 mg/kg I. P.), flumazenil (2 mg/kg I. P.), clonidine (0.01 mg/kg I. P.), isoproterenol (0.3 mg/kg I. P.), haloperidol (0.3 mg/kg I. P.), WAY 100 635 (3 mg/kg I. P.), P-chlorophenylalanine (250 mg/kg I. P., twice per day for 2 days), forskolin (3 mg/kg I. P.) and rolipram (0.173 mg/kg I. P.) did not modify the sedative effect of 30 mg/kg hesperidin. However, the sedative effect of this compound was potentiated by yohimbine (1.25 mg/kg I. P.) and buspirone (1 mg/kg I. P.), and reverted by pretreatment with aminophylline (30 mg/kg I. P.), caffeine (30 mg/kg I. P.) and several doses of 1,3-dimethyl-8-phenylxanthine (10, 30 and 54.7 mg/kg I. P.). These results suggest that adenosine receptors might be involved in the sedative action of hesperidin, identified as the active principle of the flowers of Citrus sinensis. |
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Authors:
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Silvia Laura Guzmán-Gutiérrez; Andrés Navarrete |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-13 |
Journal Detail:
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Title: Planta medica Volume: 75 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
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Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Citrus sinensis / chemistry* Dose-Response Relationship, Drug Drug Synergism Flowers / chemistry* Hesperidin / antagonists & inhibitors, chemistry*, pharmacology* Hypnotics and Sedatives / chemistry, pharmacology* Male Medicine, Traditional Mexico Mice |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 520-26-3/Hesperidin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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