| Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA). | |
| | |
MedLine Citation:
|
PMID: 22512905 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator possessing cyclic phosphate ring, which is necessary for its specific biological activities. To stabilize cyclic phosphate ring of cPA, we synthesized a series of cPA derivatives. We have shown that racemic 3-S-cPA, with a phosphate oxygen atom replaced with a sulfur atom at the sn-3, was a more effective autotaxin (ATX) inhibitor than cPA. In this study, we showed that racemic 3-S-cPA also had potent biological activities such as inhibition of cancer cell migration, suppression of the nociceptive reflex, and attenuation of ischemia-induced delayed neuronal cell death in the hippocampal CA1. Moreover, we synthesized both enantiomers of palmitoleoyl derivative of 3-S-cPA, and found that the chirality of 3-S-cPA is not involved in ATX inhibition. Based on these findings, racemic 3-S-cPA is suggested as an effective therapeutic compound like cPA. |
| | |
Authors:
|
Emi Nozaki; Mari Gotoh; Ryo Tanaka; Masaru Kato; Takahiro Suzuki; Atsuo Nakazaki; Harumi Hotta; Susumu Kobayashi; Kimiko Murakami-Murofushi |
Related Documents
:
|
4120605 - Cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural impli... 7406275 - Effect of hyaluronic acid in naturally occurring and experimentally induced osteoarthri... 6895375 - Effect of cycloheximide and dexamethasone phosphate on hyaluronic acid synthesis and se... 16298895 - The effects of different decalcification protocols on tunel and general cartilage stain... 11086725 - Synthesis and properties of chiral peptide nucleic acids with a n-aminoethyl-d-proline ... 15763595 - Synthesis of the catechols of natural and synthetic estrogens by using 2-iodoxybenzoic ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-3 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Graduate School of Humanities and Sciences, Department of Life Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Direct and Selective Benzylic Oxidation of Alkylarenes via C-H Abstraction Using Alkali Metal Bromid...
Next Document: Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)ph...