Document Detail

Pharmacological effects of latanoprost, prostaglandin E2, and F2alpha on isolated rabbit ciliary artery.
MedLine Citation:
PMID:  11931077     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Latanoprost is a prostaglandin (PG)F2alpha analogue widely recognized in the treatment of glaucoma. To investigate the action of this drug on the ocular circulation, we have studied its effects on isolated rabbit ciliary artery. The data obtained on this drug are compared with the data from PGE2 and PGF2alpha. METHODS: Under the microscope, ciliary artery specimens were prepared from rabbit eyes and mounted in a myograph system. The effects of latanoprost, PGE2, and PGF2alpha on the isolated rabbit ciliary artery were investigated in vitro using isometric tension recording methods. RESULTS: Exogenously applied PGF2alpha, but not latanoprost, evoked contraction in the rabbit ciliary artery. After precontraction with excess-[K]0 solution, latanoprost evoked relaxation dose-dependently. Latanoprost at a concentration of 100 microM induced maximum relaxation, which was not blocked by 10 microM L-nitro-L-arginine methylester (L-NAME), 1 microM 8-37 calcitonin gene-related peptide (CGRP) or 10 microM indomethacin. Moreover, latanoprost induced relaxation even in preparations without endothelium. The maximum relaxation obtained with PGE2 was somewhat less than 50% of that with latanoprost. CONCLUSIONS: These results indicate that latanoprost and PGE2 relaxed rabbit ciliary artery to different degrees. The relaxation provoked by latanoprost was not dependent on endothelium and was not caused by intrinsic PG, CGRP or nitric oxide. The mechanism of this relaxation is not yet clear.
Hitoshi Ishikawa; Takeshi Yoshitomi; Kimiyo Mashimo; Motoi Nakanishi; Kimiya Shimizu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  240     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-10-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
Department of Ophthalmology, Kitasato University, Sagamihara, Japan.
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MeSH Terms
Calcitonin Gene-Related Peptide / pharmacology
Ciliary Arteries / drug effects*
Dinoprost / pharmacology*
Dinoprostone / pharmacology*
Dose-Response Relationship, Drug
Indomethacin / pharmacology
Isometric Contraction / physiology
Muscle, Smooth, Vascular / physiology*
NG-Nitroarginine Methyl Ester / pharmacology
Prostaglandins F, Synthetic / pharmacology*
Vasoconstriction / physiology
Vasodilation / physiology*
Reg. No./Substance:
0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost; 363-24-6/Dinoprostone; 50903-99-6/NG-Nitroarginine Methyl Ester; 53-86-1/Indomethacin; 551-11-1/Dinoprost; 83652-28-2/Calcitonin Gene-Related Peptide

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