Document Detail

Pharmacological effects of iloprost (ZK 36 374), a stable prostacyclin analogue, in man.
MedLine Citation:
PMID:  6083786     Owner:  NLM     Status:  MEDLINE    
Iloprost, a stable analogue of carbaprostacyclin, was infused for 72 h to 9 patients with advanced obliterative arterial disease. Total peripheral and pulmonary vascular resistances and blood pressure were decreased. Cardiac output was elevated with no marked extra cardiac load. The glomerular filtration rate was increased and tubular reabsorption of sodium and water reduced. Consequently, urine excretion increased. The renin-angiotensin system was not activated but excretion of renal kallikrein was augmented. Several patients showed clinical improvement. The drug was well tolerated except for gastrointestinal side-effects with the dose of 4 ng X kg-1 X min-1 or more.
P Ylitalo; S Kaukinen; E Seppäla; A K Nurmi; T Pessi; T Krais; H Vapaatalo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  43     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-05     Completed Date:  1985-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  S399-402     Citation Subset:  IM    
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MeSH Terms
Arteriosclerosis Obliterans / drug therapy,  physiopathology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Cardiovascular Agents / diagnostic use*
Epoprostenol / therapeutic use*
Glomerular Filtration Rate / drug effects
Kallikreins / urine
Kidney / physiopathology
Middle Aged
Pulmonary Circulation / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Cardiovascular Agents; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost; EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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