| Pharmacological effects of iloprost (ZK 36 374), a stable prostacyclin analogue, in man. | |
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MedLine Citation:
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PMID: 6083786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iloprost, a stable analogue of carbaprostacyclin, was infused for 72 h to 9 patients with advanced obliterative arterial disease. Total peripheral and pulmonary vascular resistances and blood pressure were decreased. Cardiac output was elevated with no marked extra cardiac load. The glomerular filtration rate was increased and tubular reabsorption of sodium and water reduced. Consequently, urine excretion increased. The renin-angiotensin system was not activated but excretion of renal kallikrein was augmented. Several patients showed clinical improvement. The drug was well tolerated except for gastrointestinal side-effects with the dose of 4 ng X kg-1 X min-1 or more. |
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Authors:
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P Ylitalo; S Kaukinen; E Seppäla; A K Nurmi; T Pessi; T Krais; H Vapaatalo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedica biochimica acta Volume: 43 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1984 |
Date Detail:
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Created Date: 1985-02-05 Completed Date: 1985-02-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: S399-402 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteriosclerosis Obliterans / drug therapy, physiopathology* Blood Pressure / drug effects Cardiac Output / drug effects Cardiovascular Agents / diagnostic use* Epoprostenol / therapeutic use* Female Glomerular Filtration Rate / drug effects Humans Iloprost Kallikreins / urine Kidney / physiopathology Male Middle Aged Pulmonary Circulation / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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