Document Detail

Pharmacological effects of extracts from Valeriana adscendens Trel. II. Effects on GABA uptake and amino acids.
MedLine Citation:
PMID:  12820236     Owner:  NLM     Status:  MEDLINE    
Methanolic and aqueous extracts from Valeriana adscendens (Valerianaceae), that previously demonstrated neuroleptic-like properties, were studied for their effects on GABA uptake and amino acid neurotransmitter levels. The methanolic estract showed a significant effect in inhibiting GABA uptake and in decreasing the intracellular content of amino acid neurotransmitters in crude synaptosomes of rat. The data obtained could explain the neuroleptic activity of methanolic extract of the plant and confirm its traditional use.
Vincenzo De Feo; Carlos Faro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  17     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2003-09-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  661-4     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Fisciano (Salerno), Italy.
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MeSH Terms
Antipsychotic Agents / administration & dosage,  pharmacology*,  therapeutic use
Neurotransmitter Agents / metabolism
Plant Components, Aerial
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Rats, Wistar
Synaptosomes / drug effects*,  metabolism*
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Neurotransmitter Agents; 0/Plant Extracts; 56-12-2/gamma-Aminobutyric Acid

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