| Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig. | |
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MedLine Citation:
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PMID: 5482579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A whole-body plethysmographic technique was developed and then used to detect experimentally induced asthma in guinea pigs and to assess pharmacological treatments of allergic and classically conditioned attacks. Inhalation of a beta adrenergic compound (isoproterenol) controlled both forms of attack. Atropine and methscopolamine, parasympathetic blocking agents, prevented conditional but not allergic attacks; diphenhydramine, an antihistamine, prevented allergic attacks; and methysergide, which blocks serotonin (which is believed to trigger human asthma), prevented neither. The guinea pig's allergic reaction is probably the result of a bronchospasm induced by histamine released in tissue of the airway by a local combination of allergen and antibody. The conditional attack is believed to be a constriction of the airway mediated by parasympathetic fibers of central origin. |
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Authors:
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D R Justesen; E W Braun; R G Garrison; R B Pendleton |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 170 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1970 Nov |
Date Detail:
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Created Date: 1971-01-13 Completed Date: 1971-01-13 Revised Date: 2011-12-08 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 864-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / drug therapy*, etiology Atropine / therapeutic use Conditioning (Psychology)* Conditioning, Classical Diphenhydramine / therapeutic use Guinea Pigs Hypersensitivity / drug therapy* Isoproterenol / therapeutic use Methysergide / therapeutic use Plethysmography |
| Chemical | |
Reg. No./Substance:
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361-37-5/Methysergide; 51-55-8/Atropine; 58-73-1/Diphenhydramine; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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