Document Detail

Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig.
MedLine Citation:
PMID:  5482579     Owner:  NLM     Status:  MEDLINE    
A whole-body plethysmographic technique was developed and then used to detect experimentally induced asthma in guinea pigs and to assess pharmacological treatments of allergic and classically conditioned attacks. Inhalation of a beta adrenergic compound (isoproterenol) controlled both forms of attack. Atropine and methscopolamine, parasympathetic blocking agents, prevented conditional but not allergic attacks; diphenhydramine, an antihistamine, prevented allergic attacks; and methysergide, which blocks serotonin (which is believed to trigger human asthma), prevented neither. The guinea pig's allergic reaction is probably the result of a bronchospasm induced by histamine released in tissue of the airway by a local combination of allergen and antibody. The conditional attack is believed to be a constriction of the airway mediated by parasympathetic fibers of central origin.
D R Justesen; E W Braun; R G Garrison; R B Pendleton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  170     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1970 Nov 
Date Detail:
Created Date:  1971-01-13     Completed Date:  1971-01-13     Revised Date:  2011-12-08    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  864-6     Citation Subset:  IM    
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MeSH Terms
Asthma / drug therapy*,  etiology
Atropine / therapeutic use
Conditioning (Psychology)*
Conditioning, Classical
Diphenhydramine / therapeutic use
Guinea Pigs
Hypersensitivity / drug therapy*
Isoproterenol / therapeutic use
Methysergide / therapeutic use
Reg. No./Substance:
361-37-5/Methysergide; 51-55-8/Atropine; 58-73-1/Diphenhydramine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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