Document Detail


Pharmacological control of local oxygen regulation mechanisms in brain tissue.
MedLine Citation:
PMID:  960168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of several agents active on autonomic nervous system functions was tested on brain oxygen autoregulation parameters. It was found that atropine, propranolol and isoproterenol had no influence in abolishing the measured parameters. Phenoxybenzamine, tolazoline and dibenamine all suppress autoregulation. In an additional experimental series, a phenoxybenzamine infusion was given during O2 breathing. The infusion induced, in most cases, an additional rise in TpO2 (tissue pressure of oxygen, which refers to the partial pressure [in mm Hg] of this gas at the measuring tip of the electrode). It is concluded that an alpha-adrenergic mechanism is part of the autoregulation process. Also, the increase in brain TpO2 induced by 59% O2-5% Co2 breathing seems to be blocked or reversed by alpha-adrenolytic drugs, thus supporting the thinking that the effect of CO2 on cerebral blood flow is at least in part mediated through an alpha-adrenergic response.
Authors:
H I Bicher; P Marvin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  7     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1976 Sep-Oct
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  469-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Bemegride / pharmacology
Brain / drug effects*,  metabolism
Cats
Cerebrovascular Circulation / drug effects
Dibenzylchlorethamine / pharmacology
Homeostasis / drug effects*
Nitrogen / pharmacology
Oxygen / blood
Oxygen Consumption / drug effects*
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Tolazoline / pharmacology
Chemical
Reg. No./Substance:
51-50-3/Dibenzylchlorethamine; 51-55-8/Atropine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine; 59-98-3/Tolazoline; 64-65-3/Bemegride; 7727-37-9/Nitrogen; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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