Document Detail

Pharmacological and chemical effects of cigarette additives.
MedLine Citation:
PMID:  17666709     Owner:  NLM     Status:  MEDLINE    
We investigated tobacco industry documents and other sources for evidence of possible pharmacological and chemical effects of tobacco additives. Our findings indicated that more than 100 of 599 documented cigarette additives have pharmacological actions that camouflage the odor of environmental tobacco smoke emitted from cigarettes, enhance or maintain nicotine delivery, could increase the addictiveness of cigarettes, and mask symptoms and illnesses associated with smoking behaviors. Whether such uses were specifically intended for these agents is unknown. Our results provide a clear rationale for regulatory control of tobacco additives.
Michael Rabinoff; Nicholas Caskey; Anthony Rissling; Candice Park
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-07-31
Journal Detail:
Title:  American journal of public health     Volume:  97     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-24     Completed Date:  2007-11-05     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1981-91     Citation Subset:  AIM; IM    
Semel Institute for Neuroscience and Human Behavior and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-6968, USA.
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MeSH Terms
Ammonia / adverse effects,  analysis
Behavior, Addictive* / physiopathology
Brain / drug effects*,  physiopathology
Cognition / drug effects
Drug Synergism
Evoked Potentials
Nicotine / adverse effects*,  metabolism*
Nicotinic Agonists / adverse effects,  analysis
Plants, Toxic* / adverse effects
Smoking / adverse effects,  epidemiology*
Tobacco / adverse effects,  chemistry*
Tobacco Industry*
Tobacco Smoke Pollution / analysis
United States / epidemiology
Grant Support
Reg. No./Substance:
0/Nicotinic Agonists; 0/Tobacco Smoke Pollution; 54-11-5/Nicotine; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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