| Pharmacological characterization of central alpha-adrenoceptors which mediate clonidine-induced locomotor hypoactivity in the developing rat. | |
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MedLine Citation:
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PMID: 6245376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present experiment was designed to pharmacologically characterize receptors which mediate the clonidine-induced locomotor change in the developing rat. A subcutaneous injection of clonidine (0.78 mumol/kg) produced locomotor hyperactivity in 7-day-old rats but hypoactivity in 20-day-old rats. Phenoxybenzamine (1.5 mumol/kg, 5.9 mumol/kg and 15 mumol/kg) decreased spontaneous activity in a dose-dependent manner but did not antagonize clonidine-induced hypoactivity in 20-day-old rats. By contrast, the significant reversal of the clonidine-induced hypoactivity by pretreatment with phentolamine (1.6 mumol/kg and 6.3 mumol/kg), yohimbine (1.3 mumol/kg and 5.1 mumol/kg) and piperoxan (7.4 mumol/kg) was observed at such doses when the blockers did not cause any hypoactivity by themselves. It is suggested that clonidine could induce locomotor hypoactivity by activating presynaptic (alpha 2-type) alpha-adrenoceptors in the CNS of 20-day-old rat. |
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Authors:
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Y Nomura; K Oki; T Segawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 311 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-06-25 Completed Date: 1980-06-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Central Nervous System / drug effects* Clonidine / pharmacology* Female Male Motor Activity / drug effects* Phentolamine / pharmacology Piperoxan / pharmacology Rats Receptors, Adrenergic / drug effects* Receptors, Adrenergic, alpha / drug effects* Time Factors Yohimbine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 146-48-5/Yohimbine; 4205-90-7/Clonidine; 50-60-2/Phentolamine; 59-39-2/Piperoxan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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