| Pharmacological characterization of beta-endorphin- and dynorphin A(1-17)-induced feeding using G-protein alpha-subunit antisense probes in rats. | |
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MedLine Citation:
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PMID: 12126737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antisense (AS) oligodeoxynucleotides targeting G-protein alpha-subunits distinguish feeding responses of morphine and its metabolite, as well as nocturnal and deprivation-induced feeding. The present study examined whether feeding elicited by beta-endorphin (betaEND) or dynorphin A(1-17) was altered by ventricularly-applied G(i)alpha(1), G(i)alpha(2), G(i)alpha(3), G(s)alpha, G(o)alpha, G(q)alpha or G(x/z)alpha AS probes, or a nonsense (NS) control. The betaEND-induced feeding was reduced by the G(i)alpha(1) and G(x/z)alpha AS probes, and increased by G(i)alpha(2) or G(i)alpha(3) AS treatment. Dynorphin-induced feeding was attenuated by G(i)alpha(1) and G(o)alpha AS treatment. Yet, G(s)alpha or G(q)alpha AS and NS treatments failed to alter opioid agonist-induced feeding. These data provide initial characterization of potential effector signaling pathways mediating betaEND and dynorphin-induced feeding. |
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Authors:
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Robert M Silva; Henya C Grossman; Grace C Rossi; Gavril W Pasternak; Richard J Bodnar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 23 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2003-03-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 1101-6 Citation Subset: IM |
Affiliation:
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Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dynorphins / chemistry*, metabolism* Feeding Behavior / drug effects GTP-Binding Proteins / metabolism* Male Narcotics / agonists Oligonucleotides, Antisense / pharmacology* Protein Structure, Tertiary Rats Rats, Sprague-Dawley Signal Transduction beta-Endorphin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DA00220/DA/NIDA NIH HHS; DA00310/DA/NIDA NIH HHS; DA07274/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 0/Oligonucleotides, Antisense; 60617-12-1/beta-Endorphin; 74913-18-1/Dynorphins; EC 3.6.1.-/GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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